Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in tumour immunity. Here we elucidated the role of tumour-intri...

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Dades bibliogràfiques
Publicat a:Gut
Autors principals: Zhou, Jingying, Liu, Man, Sun, Hanyong, Feng, Yu, Xu, Liangliang, Chan, Anthony W H, Tong, Joanna H, Wong, John, Chong, Charing Ching Ning, Lai, Paul B S, Wang, Hector Kwong-Sang, Tsang, Shun-Wa, Goodwin, Tyler, Liu, Rihe, Huang, Leaf, Chen, Zhiwei, Sung, Joseph JY, Chow, King Lau, To, Ka Fai, Cheng, Alfred Sze-Lok
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961939/
https://ncbi.nlm.nih.gov/pubmed/28939663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-314032
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