A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease

Currently, drug discovery approaches focus on the design of therapies that alleviate an index symptom by reengineering the underlying biological mechanism in agonistic or antagonistic fashion. For example, medicines are routinely developed to target an essential gene that drives the disease mechanis...

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Bibliografske podrobnosti
izdano v:AMIA Jt Summits Transl Sci Proc
Main Authors: Shameer, Khader, Dow, Garrett, Glicksberg, Benjamin S., Johnson, Kipp W., Ze, Yi, Tomlinson, Max S., Readhead, Ben, Dudley, Joel T., Kullo, Iftikhar J.
Format: Artigo
Jezik:Inglês
Izdano: American Medical Informatics Association 2018
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961807/
https://ncbi.nlm.nih.gov/pubmed/29888052
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