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A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease

Currently, drug discovery approaches focus on the design of therapies that alleviate an index symptom by reengineering the underlying biological mechanism in agonistic or antagonistic fashion. For example, medicines are routinely developed to target an essential gene that drives the disease mechanis...

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Bibliografiske detaljer
Udgivet i:AMIA Jt Summits Transl Sci Proc
Main Authors: Shameer, Khader, Dow, Garrett, Glicksberg, Benjamin S., Johnson, Kipp W., Ze, Yi, Tomlinson, Max S., Readhead, Ben, Dudley, Joel T., Kullo, Iftikhar J.
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Informatics Association 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961807/
https://ncbi.nlm.nih.gov/pubmed/29888052
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