Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma

BACKGROUND: Standard therapy for chordoma consists of surgical resection followed by high-dose irradiation. Protein phosphatase 2A (PP2A) is a ubiquitously expressed serine/threonine phosphatase involved in signal transduction, cell cycle progression, cell differentiation, and DNA repair. LB100 is a...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Hao, Shuyu, Song, Hua, Zhang, Wei, Seldomridge, Ashlee, Jung, Jinkyu, Giles, Amber J, Hutchinson, Marsha-Kay, Cao, Xiaoyu, Colwell, Nicole, Lita, Adrian, Larion, Mioara, Maric, Dragan, Abu-Asab, Mones, Quezado, Martha, Kramp, Tamalee, Camphausen, Kevin, Zhuang, Zhengping, Gilbert, Mark R, Park, Deric M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961117/
https://ncbi.nlm.nih.gov/pubmed/29294092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox241
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