Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension

Telomere maintenance protects the cell against genome instability and senescence. Accelerated telomere attrition is a characteristic of premature aging syndromes including Dyskeratosis congenita (DC). Mutations in hRTEL1 are associated with a severe form of DC called Hoyeraal-Hreidarsson syndrome (H...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Porreca, Rosa M, Glousker, Galina, Awad, Aya, Matilla Fernandez, Maria I, Gibaud, Anne, Naucke, Christian, Cohen, Scott B, Bryan, Tracy M, Tzfati, Yehuda, Draskovic, Irena, Londoño-Vallejo, Arturo
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Genome Integrity, Repair and Replication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961080/
https://ncbi.nlm.nih.gov/pubmed/29522136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky173
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