Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics

For LC-MS-based targeted quantification of biotherapeutics and biomarkers in clinical and pharmaceutical environments, high sensitivity, high throughput, and excellent robustness are all essential but remain challenging. For example, though nano-LC-MS has been employed to enhance analytical sensitiv...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Zhang, Ming, An, Bo, Qu, Yang, Shen, Shichen, Fu, Wei, Chen, Yuan-Ju, Wang, Xue, Young, Rebeccah, Canty, John M, Balthasar, Joseph P, Murphy, Keeley, Bhattacharyya, Debadeep, Josephs, Jonathan, Ferrari, Luca, Zhou, Shaolian, Bansal, Surendra, Vazvaei, Faye, Qu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960441/
https://ncbi.nlm.nih.gov/pubmed/29276835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03949
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