Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes

BACKGROUND: Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Multiple laboratory findings indicate that calcitriol may be a potential treatmen...

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Bibliografiske detaljer
Udgivet i:J Biomed Sci
Main Authors: Lee, Ting-Wei, Lee, Ting-I, Lin, Yung-Kuo, Kao, Yu-Hsun, Chen, Yi-Jen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960138/
https://ncbi.nlm.nih.gov/pubmed/29776409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0443-3
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