Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition

BACKGROUND: Cancer-associated fibroblasts (CAFs) support tumour progression and invasion, and they secrete abundant extracellular matrix (ECM) that may shield tumour cells from immune checkpoint or kinase inhibitors. Targeting CAFs using drugs that revert their differentiation, or inhibit their tumo...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kim, Dae Joong, Dunleavey, James M., Xiao, Lin, Ollila, David W., Troester, Melissa A., Otey, Carol A., Li, Wei, Barker, Thomas H., Dudley, Andrew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959903/
https://ncbi.nlm.nih.gov/pubmed/29695769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0072-3
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