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Mechanism of Action of the Cytotoxic Asmarine Alkaloids
The asmarines are a family of cytotoxic natural products whose mechanism of action is unknown. Here we used chemical synthesis to reverse engineer the asmarines and understand the functions of their individual components. We found that the potent asmarine analog “delmarine” arrested the mammalian ce...
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| Vydáno v: | ACS Chem Biol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5959788/ https://ncbi.nlm.nih.gov/pubmed/29653046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00096 |
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