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Nitrosopurines en route to Potently Cytotoxic Asmarines()
A nitrosopurine-ene reaction easily assembles the asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins that exceed the potency of asmarine A (1.2 μM IC(50)) and supersede the metabolites as useful leads for biolog...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4470469/ https://ncbi.nlm.nih.gov/pubmed/25580910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411493 |
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