ERF deletion rescues RAS deficiency in mouse embryonic stem cells

MEK inhibition in combination with a glycogen synthase kinase-3β (GSK3β) inhibitor, referred as the 2i condition, favors pluripotency in embryonic stem cells (ESCs). However, the mechanisms by which the 2i condition limits ESC differentiation and whether RAS proteins are involved in this phenomenon...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Mayor-Ruiz, Cristina, Olbrich, Teresa, Drosten, Matthias, Lecona, Emilio, Vega-Sendino, Maria, Ortega, Sagrario, Dominguez, Orlando, Barbacid, Mariano, Ruiz, Sergio, Fernandez-Capetillo, Oscar
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959239/
https://ncbi.nlm.nih.gov/pubmed/29650524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.310086.117
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