Epithelial-to-mesenchymal transition antagonizes response to targeted therapies in lung cancer by suppressing BIM

PURPOSE: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. EXPERIMENTAL DESIGN: We have developed several models of EMT-mediated resi...

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Published in:Clin Cancer Res
Main Authors: Song, Kyung-A, Niederst, Matthew J., Lochmann, Timothy L., Hata, Aaron N., Kitai, Hidenori, Ham, Jungoh, Floros, Konstantinos V., Hicks, Mark A., Hu, Haichuan, Mulvey, Hillary E., Drier, Yotam, Heisey, Daniel A.R., Hughes, Mark T., Patel, Neha U., Lockerman, Elizabeth L., Garcia, Angel, Gillepsie, Shawn, Archibald, Hannah L., Gomez-Caraballo, Maria, Nulton, Tara J., Windle, Brad E., Piotrowska, Zofia, Sahingur, Sinem E., Taylor, Shirley M., Dozmorov, Mikhail, Sequist, Lecia V., Bernstein, Bradley, Ebi, Hiromichi, Engelman, Jeffrey A., Faber, Anthony C.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959009/
https://ncbi.nlm.nih.gov/pubmed/29051323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1577
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