Epithelial-to-mesenchymal transition antagonizes response to targeted therapies in lung cancer by suppressing BIM

PURPOSE: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. EXPERIMENTAL DESIGN: We have developed several models of EMT-mediated resi...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Song, Kyung-A, Niederst, Matthew J., Lochmann, Timothy L., Hata, Aaron N., Kitai, Hidenori, Ham, Jungoh, Floros, Konstantinos V., Hicks, Mark A., Hu, Haichuan, Mulvey, Hillary E., Drier, Yotam, Heisey, Daniel A.R., Hughes, Mark T., Patel, Neha U., Lockerman, Elizabeth L., Garcia, Angel, Gillepsie, Shawn, Archibald, Hannah L., Gomez-Caraballo, Maria, Nulton, Tara J., Windle, Brad E., Piotrowska, Zofia, Sahingur, Sinem E., Taylor, Shirley M., Dozmorov, Mikhail, Sequist, Lecia V., Bernstein, Bradley, Ebi, Hiromichi, Engelman, Jeffrey A., Faber, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959009/
https://ncbi.nlm.nih.gov/pubmed/29051323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1577
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