PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity

PURPOSE: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells (DCs). DC signals can be bypassed by CD27 agonists and we therefore investigat...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Buchan, Sarah L., Fallatah, Mohannad, Thirdborough, Stephen M., Taraban, Vadim Y., Rogel, Anne, Thomas, Lawrence J., Penfold, Christine A., He, Li-Zhen, Curran, Michael A., Keler, Tibor, Al-Shamkhani, Aymen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959006/
https://ncbi.nlm.nih.gov/pubmed/29514845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3057
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