Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9

Several regulators of SUMOylation have been previously linked to senescence but most targets of this modification in senescent cells remain unidentified. Using a two-step purification of a modified SUMO3, we profiled the SUMO proteome of senescent cells in a site-specific manner. We identified 25 SU...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: McManus, Francis P., Bourdeau, Véronique, Acevedo, Mariana, Lopes-Paciencia, Stéphane, Mignacca, Lian, Lamoliatte, Frédéric, Rojas Pino, John W., Ferbeyre, Gerardo, Thibault, Pierre
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958138/
https://ncbi.nlm.nih.gov/pubmed/29773808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25150-z
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