Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

Three prime repair exonuclease 1 (TREX1) is an essential exonuclease in mammalian cells, and numerous in vivo and in vitro data evidenced its participation in immunity regulation and in genotoxicity remediation. In these very complicated cellular functions, the molecular mechanisms by which duplex D...

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Библиографические подробности
Опубликовано в: :PLoS Biol
Главные авторы: Huang, Kuan-Wei, Liu, Tung-Chang, Liang, Ruei-Yue, Chu, Lee-Ya, Cheng, Hiu-Lo, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957452/
https://ncbi.nlm.nih.gov/pubmed/29734329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005653
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