Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical to induce the production of type I interferons (IFNs) and proinflammatory cytokines. While activation of the MAVS/TRAF3/TRAF6 signalosome is well studied, the negative regulation of...

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發表在:PLoS Pathog
Main Authors: Zhang, Liting, Liu, Jin, Qian, Liping, Feng, Qian, Wang, Xiaofang, Yuan, Yukang, Zuo, Yibo, Cheng, Qiao, Miao, Ying, Guo, Tingting, Zheng, Xiaofeng, Zheng, Hui
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957451/
https://ncbi.nlm.nih.gov/pubmed/29734366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007067
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