Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical to induce the production of type I interferons (IFNs) and proinflammatory cytokines. While activation of the MAVS/TRAF3/TRAF6 signalosome is well studied, the negative regulation of...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Pathog
Main Authors: Zhang, Liting, Liu, Jin, Qian, Liping, Feng, Qian, Wang, Xiaofang, Yuan, Yukang, Zuo, Yibo, Cheng, Qiao, Miao, Ying, Guo, Tingting, Zheng, Xiaofeng, Zheng, Hui
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957451/
https://ncbi.nlm.nih.gov/pubmed/29734366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007067
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items