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USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis
Overexpression of Cyclin E has been seen in many types of cancers. However, the underlying mechanism remains enigmatic. Herein, we identified ubiquitin-specific peptidase 27 (USP27) as a Cyclin E interactor. We found that USP27 promoted Cyclin E stability by negatively regulating its ubiquitination....
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| I publikationen: | Oncogene |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955865/ https://ncbi.nlm.nih.gov/pubmed/29497124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0137-z |
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