Truncated glioma-associated oncogene homolog 1 (tGLI1) mediates mesenchymal glioblastoma via transcriptional activation of CD44

The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Rimkus, Tadas K., Carpenter, Richard L., Sirkisoon, Sherona, Zhu, Dongqin, Pasche, Boris C., Chan, Michael D., Lesser, Glenn J., Tatter, Stephen B., Watabe, Kounosuke, Debinski, Waldemar, Lo, Hui-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955849/
https://ncbi.nlm.nih.gov/pubmed/29463580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2933
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