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RASSF1A deficiency enhances RAS driven lung tumorigenesis

Mutant K-RAS has been shown to have both tumor promoting and suppressing functions and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescences effectors. It has been hypothesized that inactivation of the RASSF1A tumor suppressor facilitates K-RAS...

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Publicat a:Cancer Res
Autors principals: Schmidt, M. Lee, Hobbing, Katharine R., Donninger, Howard, Clark, Geoffrey J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955812/
https://ncbi.nlm.nih.gov/pubmed/29735543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2466
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