SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia

Children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) overexpressing the CRLF2 gene (hiCRLF2) have poor prognosis. CRLF2 protein overexpression leads to activated JAK/STAT signaling and trials are underway using JAK inhibitors to overcome treatment failure. Pre-clinical studies indic...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Sarno, Jolanda, Savino, Angela M., Buracchi, Chiara, Palmi, Chiara, Pinto, Stefania, Bugarin, Cristina, Jager, Astraea, Bresolin, Silvia, Barber, Ruth C., Silvestri, Daniela, Israeli, Shai, Dyer, Martin J.S., Cazzaniga, Giovanni, Nolan, Garry P., Biondi, Andrea, Davis, Kara L., Gaipa, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955419/
https://ncbi.nlm.nih.gov/pubmed/29796158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25089
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