Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

We show that suppression of the spliceosome has potential for the treatment of cutaneous squamous cell carcinoma (cSCC). The small-molecule inhibitors of the spliceosome at the most advanced stage of development target the splicing factor SF3B1/SF3b155. The majority of cSCC cell lines are more sensi...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Hepburn, Lydia A., McHugh, Angela, Fernandes, Kenneth, Boag, Garry, Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955416/
https://ncbi.nlm.nih.gov/pubmed/29796170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25196
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk