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Global Kinetic Mechanism of Microsomal Glutathione Transferase 1, insights into dynamic enzyme activation

Microsomal glutathione transferase 1 (MGST1) has a unique ability to be activated, up to 30-fold, by modification with sulfhydryl reagents. MGST1 exhibits one-third-of-the-sites-reactivity towards glutathione and hence heterogeneous binding to different active sites in the homo-trimer. Limited turno...

詳細記述

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書誌詳細
出版年:Biochemistry
主要な著者: Spahiu, Linda, Ålander, Johan, Ottosson-Wadlund, Astrid, Svensson, Richard, Lehmer, Carina, Armstrong, Richard N., Morgenstern, Ralf
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954419/
https://ncbi.nlm.nih.gov/pubmed/28558199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00285
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