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Global Kinetic Mechanism of Microsomal Glutathione Transferase 1, insights into dynamic enzyme activation
Microsomal glutathione transferase 1 (MGST1) has a unique ability to be activated, up to 30-fold, by modification with sulfhydryl reagents. MGST1 exhibits one-third-of-the-sites-reactivity towards glutathione and hence heterogeneous binding to different active sites in the homo-trimer. Limited turno...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5954419/ https://ncbi.nlm.nih.gov/pubmed/28558199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00285 |
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