Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation

Microsomal glutathione transferase 1 (MGST1) is a detoxification enzyme belonging to the Membrane Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) superfamily. Here we have used electron crystallography of two-dimensional crystals in order to determine an atomic model of rat MGST...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kuang, Qie, Purhonen, Pasi, Ålander, Johan, Svensson, Richard, Hoogland, Veronika, Winerdal, Jens, Spahiu, Linda, Ottosson-Wadlund, Astrid, Jegerschöld, Caroline, Morgenstern, Ralf, Hebert, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554250/
https://ncbi.nlm.nih.gov/pubmed/28801553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07912-3
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