TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility

The heterotrimeric cardiac troponin complex is a key regulator of contraction and plays an essential role in conferring Ca(2+) sensitivity to the sarcomere. During ischemic injury, rapidly accumulating protons acidify the myoplasm, resulting in markedly reduced Ca(2+) sensitivity of the sarcomere. U...

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Publicat a:Biophys J
Autors principals: Vetter, Anthony D., Houang, Evelyne M., Sell, Jordan J., Thompson, Brian R., Sham, Yuk Y., Metzger, Joseph M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Molecular Machines, Motors, and Nanoscale Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954295/
https://ncbi.nlm.nih.gov/pubmed/29642034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.015
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