Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhes...

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書誌詳細
出版年:Cancer Cell
主要な著者: Churchman, Michelle L., Qian, Maoxiang, te Kronnie, Geertruy, Zhang, Ranran, Yang, Wenjian, Zhang, Hui, Lana, Tobia, Tedrick, Paige, Baskin, Rebekah, Verbist, Katherine, Peters, Jennifer L., Devidas, Meenakshi, Larsen, Eric, Moore, Ian M., Gu, Zhaohui, Qu, Chunxu, Yoshihara, Hiroki, Porter, Shaina N., Pruett-Miller, Shondra M., Wu, Gang, Raetz, Elizabeth, Martin, Paul L., Bowman, W. Paul, Winick, Naomi, Mardis, Elaine, Fulton, Robert, Stanulla, Martin, Evans, William E., Relling, Mary V., Pui, Ching-Hon, Hunger, Stephen P., Loh, Mignon L., Handgretinger, Rupert, Nichols, Kim E., Yang, Jun J., Mullighan, Charles G.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953820/
https://ncbi.nlm.nih.gov/pubmed/29681510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.03.021
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