Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

The metameric structure in vertebrates is based on the periodic formation of somites from the anterior end of the presomitic mesoderm (PSM). The segmentation boundary is defined by the Tbx6 expression domain, whose anterior limit is determined by Tbx6 protein destabilization via Ripply2. However, th...

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Bibliographic Details
Published in:eLife
Main Authors: Zhao, Wei, Oginuma, Masayuki, Ajima, Rieko, Kiso, Makoto, Okubo, Akemi, Saga, Yumiko
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953544/
https://ncbi.nlm.nih.gov/pubmed/29761784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33068
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