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ES-mediated chimera analysis revealed requirement of DDX6 for NANOS2 localization and function in mouse germ cells

In embryonic male germ cells, the RNA-binding protein NANOS2 recruits its target RNAs to processing bodies (P-bodies), where they are repressed. This process is necessary to promote male-type germ cell differentiation. However, it remains unclear whether all NANOS2 functions depend on P-bodies. To a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shimada, Ryuki, Kiso, Makoto, Saga, Yumiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345806/
https://ncbi.nlm.nih.gov/pubmed/30679547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36502-0
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