Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α(+)thalassaemia

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McC(b), occur at high frequencies, consistent with selection by malaria. Previous studies have been...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Opi, D Herbert, Swann, Olivia, Macharia, Alexander, Uyoga, Sophie, Band, Gavin, Ndila, Carolyne M, Harrison, Ewen M, Thera, Mahamadou A, Kone, Abdoulaye K, Diallo, Dapa A, Doumbo, Ogobara K, Lyke, Kirsten E, Plowe, Christopher V, Moulds, Joann M, Shebbe, Mohammed, Mturi, Neema, Peshu, Norbert, Maitland, Kathryn, Raza, Ahmed, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Rowe, J Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Epidemiology and Global Health
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953541/
https://ncbi.nlm.nih.gov/pubmed/29690995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31579
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