Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α(+)thalassaemia

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McC(b), occur at high frequencies, consistent with selection by malaria. Previous studies have been...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Opi, D Herbert, Swann, Olivia, Macharia, Alexander, Uyoga, Sophie, Band, Gavin, Ndila, Carolyne M, Harrison, Ewen M, Thera, Mahamadou A, Kone, Abdoulaye K, Diallo, Dapa A, Doumbo, Ogobara K, Lyke, Kirsten E, Plowe, Christopher V, Moulds, Joann M, Shebbe, Mohammed, Mturi, Neema, Peshu, Norbert, Maitland, Kathryn, Raza, Ahmed, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Rowe, J Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Epidemiology and Global Health
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953541/
https://ncbi.nlm.nih.gov/pubmed/29690995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31579
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky