Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway

Receptor-interacting protein 3 (Ripk3)-mediated necroptosis contributes to cardiac ischaemia-reperfusion (IR) injury through poorly defined mechanisms. Our results demonstrated that Ripk3 was strongly upregulated in murine hearts subjected to IR injury and cardiomyocytes treated with LPS and H(2)O(2...

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Pubblicato in:Redox Biol
Autori principali: Zhu, Pingjun, Hu, Shunying, Jin, Qinhua, Li, Dandan, Tian, Feng, Toan, Sam, Li, Yang, Zhou, Hao, Chen, Yundai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952878/
https://ncbi.nlm.nih.gov/pubmed/29502045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.02.019
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