All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells

BACKGROUND: Retinoic acid (RA) is an active metabolite of vitamin A and has been reported to improve the clinical symptoms of patients with systemic sclerosis (SSc). However, the mechanism of RA in the prevention of SSc remains unclear. Regulatory T cells (Tregs) are a subpopulation of T cells with...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Sun, Xiaohong, Xiao, Yangfan, Zeng, Zhuotong, Shi, Yaqian, Tang, Bingsi, Long, Hai, Kanekura, Takuro, Wang, Jiucun, Wu, Haijing, Zhao, Ming, Lu, Qianjin, Xiao, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952589/
https://ncbi.nlm.nih.gov/pubmed/29854846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8658156
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