Cryo-EM structure of human mTOR complex 2

Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) plays an essential role in regulating cell proliferation through phosphorylating AGC protein kinase family members, including AKT, PKC and SGK1. The functional core complex consists of mTOR, mLST8, and two mTORC2-specific components, Rictor a...

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Dades bibliogràfiques
Publicat a:Cell Res
Autors principals: Chen, Xizi, Liu, Mengjie, Tian, Yuan, Li, Jiabei, Qi, Yilun, Zhao, Dan, Wu, Zihan, Huang, Min, Wong, Catherine C. L., Wang, Hong-Wei, Wang, Jiawei, Yang, Huirong, Xu, Yanhui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951902/
https://ncbi.nlm.nih.gov/pubmed/29567957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0029-3
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