CO(2)-sensitive tRNA modification associated with human mitochondrial disease

It has been generally thought that tRNA modifications are stable and static, and their frequencies are rarely regulated. N(6)-threonylcarbamoyladenosine (t(6)A) occurs at position 37 of five mitochondrial (mt-)tRNA species. We show that YRDC and OSGEPL1 are responsible for t(6)A37 formation, utilizi...

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Publicado en:Nat Commun
Main Authors: Lin, Huan, Miyauchi, Kenjyo, Harada, Tai, Okita, Ryo, Takeshita, Eri, Komaki, Hirofumi, Fujioka, Kaoru, Yagasaki, Hideki, Goto, Yu-ichi, Yanaka, Kaori, Nakagawa, Shinichi, Sakaguchi, Yuriko, Suzuki, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951830/
https://ncbi.nlm.nih.gov/pubmed/29760464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04250-4
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