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Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway

Aziridine aldehyde dimers, peptides, and isocyanides participate in a multicomponent reaction to yield peptide macrocycles. We have investigated the selectivity and kinetics of this process and performed a detailed analysis of its chemoselectivity. While the reactants encompass all of the elements o...

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Vydáno v:Chem Sci
Hlavní autoři: Zaretsky, Serge, Hickey, Jennifer L., Tan, Joanne, Pichugin, Dmitry, St. Denis, Megan A., Ler, Spencer, Chung, Benjamin K. W., Scully, Conor C. G., Yudin, Andrei K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949604/
https://ncbi.nlm.nih.gov/pubmed/29861887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01958c
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