Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway

Aziridine aldehyde dimers, peptides, and isocyanides participate in a multicomponent reaction to yield peptide macrocycles. We have investigated the selectivity and kinetics of this process and performed a detailed analysis of its chemoselectivity. While the reactants encompass all of the elements o...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Zaretsky, Serge, Hickey, Jennifer L., Tan, Joanne, Pichugin, Dmitry, St. Denis, Megan A., Ler, Spencer, Chung, Benjamin K. W., Scully, Conor C. G., Yudin, Andrei K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2015
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949604/
https://ncbi.nlm.nih.gov/pubmed/29861887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01958c
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller