Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: a multicentre, open-label, phase 1 study

BACKGROUND: Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK kinases, had demonstrated activity in preclinical models and in adults with tumours harbourin...

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Dades bibliogràfiques
Publicat a:Lancet Oncol
Autors principals: Laetsch, Theodore W., DuBois, Steven G., Mascarenhas, Leo, Turpin, Brian, Federman, Noah, Albert, Catherine M., Nagasubramanian, Ramamoorthy, Davis, Jessica L., Rudzinski, Erin, Feraco, Angela M., Tuch, Brian B., Ebata, Kevin T., Reynolds, Mark, Smith, Steven, Cruickshank, Scott, Cox, Michael C., Pappo, Alberto S., Hawkins, Douglas S.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949072/
https://ncbi.nlm.nih.gov/pubmed/29606586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(18)30119-0
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