Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

BACKGROUND: Fusions involving one of three tropomyosin receptor kinases (TRK) occur in diverse cancers in children and adults. We evaluated the efficacy and safety of larotrectinib, a highly selective TRK inhibitor, in adults and children who had tumors with these fusions. METHODS: We enrolled patie...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:N Engl J Med
Prif Awduron: Drilon, A., Laetsch, T.W., Kummar, S., DuBois, S.G., Lassen, U.N., Demetri, G.D., Nathenson, M., Doebele, R.C., Farago, A.F., Pappo, A.S., Turpin, B., Dowlati, A., Brose, M.S., Mascarenhas, L., Federman, N., Berlin, J., El-Deiry, W.S., Baik, C., Deeken, J., Boni, V., Nagasubramanian, R., Taylor, M., Rudzinski, E.R., Meric-Bernstam, F., Sohal, D.P.S., Ma, P.C., Raez, L.E., Hechtman, J.F., Benayed, R., Ladanyi, M., Tuch, B.B., Ebata, K., Cruickshank, S., Ku, N.C., Cox, M.C., Hawkins, D.S., Hong, D.S., Hyman, D.M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857389/
https://ncbi.nlm.nih.gov/pubmed/29466156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1714448
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