Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: a multicentre, open-label, phase 1 study

BACKGROUND: Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule inhibitor of the TRK kinases, had demonstrated activity in preclinical models and in adults with tumours harbourin...

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Gepubliceerd in:Lancet Oncol
Hoofdauteurs: Laetsch, Theodore W., DuBois, Steven G., Mascarenhas, Leo, Turpin, Brian, Federman, Noah, Albert, Catherine M., Nagasubramanian, Ramamoorthy, Davis, Jessica L., Rudzinski, Erin, Feraco, Angela M., Tuch, Brian B., Ebata, Kevin T., Reynolds, Mark, Smith, Steven, Cruickshank, Scott, Cox, Michael C., Pappo, Alberto S., Hawkins, Douglas S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949072/
https://ncbi.nlm.nih.gov/pubmed/29606586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(18)30119-0
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