Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia

PURPOSE: Acute myeloid leukemia (AML) is a heterogeneous disease with poor outcomes. Despite increased evidence shows that dysregulation of histone modification contributes to AML, specific drugs targeting key histone modulators are not applied in the clinical treatment of AML. Here, we investigated...

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Detalhes bibliográficos
Publicado no:J Cancer Res Clin Oncol
Main Authors: Li, Yunan, Zhang, Mingying, Sheng, Mengyao, Zhang, Peng, Chen, Zizhen, Xing, Wen, Bai, Jie, Cheng, Tao, Yang, Feng-Chun, Zhou, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Original Article – Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948279/
https://ncbi.nlm.nih.gov/pubmed/29594337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-018-2631-7
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