Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

Recombinant adeno-associated virus (rAAV)-based gene therapy has entered a phase of clinical translation and commercialization. Despite this progress, vector integrity following production is often overlooked. Compromised vectors may negatively impact therapeutic efficacy and safety. Using single mo...

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Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Tai, Phillip W.L., Xie, Jun, Fong, Kaiyuen, Seetin, Matthew, Heiner, Cheryl, Su, Qin, Weiand, Michael, Wilmot, Daniella, Zapp, Maria L., Gao, Guangping
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948225/
https://ncbi.nlm.nih.gov/pubmed/29766023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.02.002
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