Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector

Efforts to develop drugs for Alzheimer’s disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells carrying the major genetic risk factor apolipoprote...

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Publicat a:Nat Med
Autors principals: Wang, Chengzhong, Najm, Ramsey, Xu, Qin, Jeong, Dah-eun, Walker, David, Balestra, Maureen E., Yoon, Seo Yeon, Yuan, Heidi, Li, Gang, Miller, Zachary A., Miller, Bruce L., Malloy, Mary J., Huang, Yadong
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948154/
https://ncbi.nlm.nih.gov/pubmed/29632371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0004-z
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