Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes

Allele-specific RNA silencing has been shown to be an effective therapeutic treatment in a number of diseases, including neurodegenerative disorders. Studies of allele-specific silencing in hypertrophic cardiomyopathy (HCM) to date have focused on mouse models of disease. We here examine allele-spec...

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Опубликовано в: :Physiol Genomics
Главные авторы: Dainis, Alexandra, Zaleta-Rivera, Kathia, Ribeiro, Alexandre, Chang, Andrew Chia Hao, Shang, Ching, Lan, Feng, Burridge, Paul W., Liu, W. Robert, Wu, Joseph C., Chang, Alex Chia Yu, Pruitt, Beth L., Wheeler, Matthew, Ashley, Euan
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468691/
https://ncbi.nlm.nih.gov/pubmed/32567507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00021.2020
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