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Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids

The hapalindole-type alkaloids naturally show striking late stage diversification of what was believed to be a conserved intermediate, cis-indolyl vinyl isonitrile (1a). Here we demonstrate enzymatically, as well as through applying a synthetic biology approach, that the pathway generating 1a (itsel...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Ittiamornkul, Kuljira, Zhu, Qin, Gkotsi, Danai S., Smith, Duncan R. M., Hillwig, Matthew L., Nightingale, Nicole, Goss, Rebecca J. M., Liu, Xinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947517/
https://ncbi.nlm.nih.gov/pubmed/29861925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02919h
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