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Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: Identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase

Biochemical characterizations of aromatic prenyltransferase AmbP1 and its close homologs WelP1/FidP1 in hapalindole-type alkaloid biosynthetic pathways are reported. These enzymes mediate the magnesium-dependent selective formation of 3-geranyl 3-isocyanovinyl indolenine (2) from cis-indolyl vinyl i...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Liu, Xinyu, Hillwig, Matthew L., Koharudin, Leonardus M.I., Gronenborn, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720564/
https://ncbi.nlm.nih.gov/pubmed/26740122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc10060g
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