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Distinct chromatin signatures of DNA hypomethylation in aging and cancer

Cancer is an aging‐associated disease, but the underlying molecular links between these processes are still largely unknown. Gene promoters that become hypermethylated in aging and cancer share a common chromatin signature in ES cells. In addition, there is also global DNA hypomethylation in both pr...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Pérez, Raúl F., Tejedor, Juan Ramón, Bayón, Gustavo F., Fernández, Agustín F., Fraga, Mario F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946083/
https://ncbi.nlm.nih.gov/pubmed/29504244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12744
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