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Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to DNA methylation. Here, we characterize the blood DNA methylome across 16 age groups of mice and report numerous global, region‐ and site‐specific fe...

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Bibliographische Detailangaben
Veröffentlicht in:Aging Cell
Hauptverfasser: Sziráki, András, Tyshkovskiy, Alexander, Gladyshev, Vadim N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946071/
https://ncbi.nlm.nih.gov/pubmed/29575528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12738
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