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Direct neurotransmitter activation of voltage-gated potassium channels
Voltage-gated potassium channels KCNQ2–5 generate the M-current, which controls neuronal excitability. KCNQ2–5 subunits each harbor a high-affinity anticonvulsant drug-binding pocket containing an essential tryptophan (W265 in human KCNQ3) conserved for >500 million years, yet lacking a known phy...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5945843/ https://ncbi.nlm.nih.gov/pubmed/29748663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04266-w |
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