p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Inhibition of APAP metabolic activation and promotion in APAP disposition are important to protect against APAP-induced liver injury. Tumor suppressor p53 is traditionally recognized as a surveillance molec...

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Publicat a:Cell Death Dis
Autors principals: Sun, Jiahong, Wen, Yajie, Zhou, Yanying, Jiang, Yiming, Chen, Yixin, Zhang, Huizheng, Guan, Lihuan, Yao, Xinpeng, Huang, Min, Bi, Huichang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945795/
https://ncbi.nlm.nih.gov/pubmed/29748533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0507-z
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