SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 (SIRT6) has been reported to protect against oxidative stress-associated DNA damage. But whether SIRT6 regulates APAP-induced...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Zhou, Yanying, Fan, Xiaomei, Jiao, Tingying, Li, Wenzhou, Chen, Panpan, Jiang, Yiming, Sun, Jiahong, Chen, Yixin, Chen, Pan, Guan, Lihuan, Wen, Yajie, Huang, Min, Bi, Huichang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7838028/
https://ncbi.nlm.nih.gov/pubmed/33532182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.06.016
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